Basic information of S1PR1 :
| Official Symbol of Gene | S1PR1 |
| Species | Homo sapiens |
| Entrez Gene ID | 1901 |
| Official Full Name | sphingosine-1-phosphate receptor 1 |
| Also known as | EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000170989 MIM:601974; AllianceGenome:HGNC:3165 |
| Map Location | 1p21.2 |
| Variation Type | DNA methylation |
| refSNP ID | DNA methylation |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | autoimmune diseases |
| Disease subtype | N/A |
| Population | CHO-K1 and 293T cells |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 25293589 |
| Year | 2014 |
| Title | Individual variation of human S1P 1 coding sequence leads to heterogeneity in receptor function and drug interactions |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | This study suggests that individual genetic variations of S1P 1 can infl uence receptor function and, therefore, infer differential disease risks and interaction with S1P 1 -targeted therapeutics |
| Result | In summary, fi ndings in this study suggest that individual variations in S1P 1 may infl uence cardiovascular/immune functions as well as drug sensitivity and, therefore, infer differential risks for cardiovascular and autoimmune diseases as well as response to S1P receptor modulatory drugs. Suffi ciently powered prospective cohort studies should be conducted to validate possible relationships between individual variations in the S1P 1 receptor and specifi c diseases/drug sensitivity |
| Mechanism/Pathway | One SNP mutant (Arg 120 to Pro) failed to transmit sphingosine 1-phosphate (S1P)-induced intracellular signals such as calcium increase and activation of p44/42 MAPK and Akt |
