Basic information of FCRL3 :

Official Symbol of Gene	FCRL3
Species	Homo sapiens
Entrez Gene ID	115352
Official Full Name	Fc receptor like 3
Also known as	MAIA; FCRH3; IFGP3; IRTA3; SPAP2; CD307c
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000160856 MIM:606510; AllianceGenome:HGNC:18506
Map Location	1q23.1
Variation Type	SNP
refSNP ID	rs7528684

Sample information of multiple sclerosis:

Detected Sample	venous blood
Sample Detail	N/A
Detected Method	PCR
Disease	Neuromyelitis optica (NMO)
Disease subtype	N/A
Population	N/A
Sample Size	132 NMO patients/264 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	26402798
Year	2015
Title	The Fc Receptor-Like 3 Polymorphisms (rs7528684, rs945635, rs3761959 and rs2282284) and The Risk of Neuromyelitis Optica in A Chinese Population

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Distribution of Genotype Frequency and the Risk of NMO The case-control analysis demonstrated that rs7528684 (FCRL3_3), rs945635 (FCRL3_5), rs3761959 (FCRL3_6), and rs2282284 (FCRL3_8) showed significant associations with risk of NMO, whereas other 3 SNPs were not. To be specific, the FCRL3_3C, FCRL3_5C, FCRL3_6A, FCRL3_8G allelic frequencies were significantly higher in the case group than those in the control group (OR 1.50, 95% CI: 1.11–2.03, P 0.008; OR 1.44, 95% CI: 1.07–1.94, P 0.015; OR 1.45, 95% CI: 1.08–1.95, P 0.014; OR 2.01, 95% CI: 1.13–3.60, P 0.016). Moreover, their recessive models (except rs3761959) and homozygous models also revealed the remarkable associations between the genetic variants and the risk of NMO. However, the dominant models or the allelic models failed to show any significant correlations between the rest 3 SNPs and the risk of NMO. In addition, haplotype analysis showed that FCRL3_3C, FCRL3_6A, and FCRL3_8G were in a strong linkage disequilibrium (LD), except FCRL3_5
Result	Conclusions in the present study could be drawn that 4 SNPs in FCRL3 (FCRL3_3C, 5C, 6A, 8G) might account for increased risk of NMO in a Chinese-Han population. Nevertheless, further cohort studies are in demand to validate the association in the future
Mechanism/Pathway	FCRL3 encoded a member of the immunoglobulin receptor superfamily, which could directly act against myelin-derived antigens.16 Furthermore, although the precise function of FCRL3 remains to be unknown, the contained immunoreceptor-tyrosine inhibitory motifs (ITIMs) and immunoreceptor-tyrosine activation motifs (ITAMs) are deemed to be involved in the regulation of the immune system