Basic information of TNFSF13B :
| Official Symbol of Gene | TNFSF13B |
| Species | Homo sapiens |
| Entrez Gene ID | 10673 |
| Official Full Name | TNF superfamily member 13b |
| Also known as | DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNLG7A; TNFSF20 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000102524 MIM:603969; AllianceGenome:HGNC:11929 |
| Map Location | 13q33.3 |
| Variation Type | SNP |
| refSNP ID | rs374039502 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | white blood cells |
| Detected Method | TaqMan assay |
| Disease | N/A |
| Disease subtype | giant cell arteritis (GCA) and systemic sclerosis (SSc) |
| Population | European |
| Sample Size | 1,728 biopsy-proven GCA patients from 4 European cohorts, 4,584 SSc patients from 3 European cohorts and 5,160 ethnically-matched healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 30586461 |
| Year | 2018 |
| Title | A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | In conclusion, in the present study we have failed to identify an association between the TNFSF13B functional variant previously associated with autoimmunity and two immunerelated diseases, GCA and SSc. Thus, this genetic variant does not seem to be responsible for the increased levels of BAFF found in these disorders |
| Result | Our data suggest that the TNFSF13B functional variant does not contribute to the genetic network underlying GCA and SSc |
| Mechanism/Pathway | The TNFSF13B (TNF superfamily member 13b) gene encodes BAFF, a cytokine with a crucial role in the differentiation and activation of B cells |
