Basic information of CETP :

Official Symbol of Gene	CETP
Species	Homo sapiens
Entrez Gene ID	1071
Official Full Name	cholesteryl ester transfer protein
Also known as	BPIFF; HDLCQ10
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000087237 MIM:118470; AllianceGenome:HGNC:1869
Map Location	16q13
Variation Type	SNP
refSNP ID	rs708272

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	N/A
Detected Method	RT-PCR
Disease	ON
Disease subtype	N/A
Population	N/A
Sample Size	63 subjects with a diagnosis of optic neuritis and 754 persons of the reference group

Literature information of multiple sclerosis :

Pubmed ID	31199170
Year	2019
Title	Does CETP rs5882, rs708272, SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, VEGFA rs833068, IL6 rs1800795 polymorphisms play a role in optic neuritis development?

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Our study determined that the G/A genotype of CETPrs708272 was associated with two-folddecreased odds of ON development under the codominant (OR = 0.495;95%CI:0.256–0.959) and overdominant (OR = 0.501;95%CI:0.280–0.895) models. Also, each allele C at VEGFArs833068 was associated with 1.7-fold increased odds of ON development under the additive model (OR = 1.733;95% CI:1.148–2.615). Furthermore, IL6 rs1800795 G/G genotype was associated with increased odds of ON development under the codominant (OR = 2.869;95%CI:1.280–6.434) and recessive (OR = 2.315;95% CI:1.251–4.285) models
Result	We revealed that the genotypes of CETPrs708272 G/A, IL6rs1800795 G/G, and each allele C at VEGFArs833068 were associated with ON. CETPrs708272 G/G genotype was associated with decreased by 62% odds of ON with MS development under the recessive (OR = 0.379;95% CI:0.155–0.929; p = .034) model
Mechanism/Pathway	It is thought that CETP, SIRT1, FGFR2, STAT3, VEGFA and IL6 genes play a key role in this autoimmune inflammatory disease