Basic information of TGFB2 :
| Official Symbol of Gene | TGFB2 |
| Species | Homo sapiens |
| Entrez Gene ID | 7042 |
| Official Full Name | transforming growth factor beta 2 |
| Also known as | LDS4; G-TSF; TGF-beta2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000092969 MIM:190220; AllianceGenome:HGNC:11768 |
| Map Location | 1q41 |
| Variation Type | N/A |
| refSNP ID | rs6658835 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 937 MS patients, 538 PD cases and 2022 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 17431704 |
| Year | 2006 |
| Title | Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson’s disease |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | We have demonstrated a trend towards association of the 5’ region of TGFB2, including the promoter region and exon 1, with PD. When coupled with the recent observation that TGFb2 appears to have a role in the maintainance of striatal dopamine levels in rodents, this finding provides some support for the hypothesis that variation in the TGFB2 gene influences susceptibility to idiopathic PD. We suggest that the relevance of marker rs6658835 should be explored in other PD cohorts |
| Result | suggesting that rs6658835*G may be the causative variant |
| Mechanism/Pathway | The transforming growth factor betas (TGFbs) control the growth, differentiation and function of a wide range of cells and have been implicated in many different disease processes |
