Basic information of PON1 :
| Official Symbol of Gene | PON1 |
| Species | Homo sapiens |
| Entrez Gene ID | 5444 |
| Official Full Name | paraoxonase 1 |
| Also known as | ESA; PON; MVCD5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000005421 MIM:168820; AllianceGenome:HGNC:9204 |
| Map Location | 7q21.3 |
| Variation Type | N/A |
| refSNP ID | polymorphismã€genotypes and allelic variants |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RLFP |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 228 unselected and unrelated patients who fulfilled the McDonald’s criteria for definite MS |
Literature information of multiple sclerosis :
| Pubmed ID | 19826962 |
| Year | 2010 |
| Title | Paraoxonase 1 Polymorphisms Are Not Related with the Risk for Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | The results of the present study suggest that PON1 polymorphism is not related with the risk for multiple sclerosis in our population |
| Result | The OR (95% confidence intervals) for the variant alleles PON155L and PON1-192R were 0.96 (0.73–1.26) and 1.01 (0.76–1.35), respectively |
| Mechanism/Pathway | The high variability in the activity of PON1 has been attributed to several polymorphisms within the gene |
