Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
| Variation Type | N/A |
| refSNP ID | rs6897932 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | white patients |
| Sample Size | 678 unrelated white patients and 597 unrelated |
Literature information of multiple sclerosis :
| Pubmed ID | 20194581 |
| Year | 2010 |
| Title | Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | It is known that demographic as well as environmental factors have a substantial role in multiple sclerosis development, as well as population genetic background. The results of this study indicate that other types of genome variants should be required for the development and/or progression of multiple sclerosis, which may vary among populations |
| Result | We found no significant difference in genotype or allele frequencies between controls and patients with multiple sclerosis either separately in Serbian, Croatian, and Slovenian populations or in the whole sample from the Western Balkans. The odds ratio for multiple sclerosis in this study was 1.04 (0.86–1.25) for the C allele |
| Mechanism/Pathway | The IL7R complex is a heterodimer consisting of the IL7R alpha (IL7RA) chain and the common gamma chain (gc).3 Alternative splicing of exon 6 of IL7RA leads to the production of a membrane-bound or a soluble form of IL7RA |
