Basic information of CLEC16A :

Official Symbol of Gene	CLEC16A
Species	Homo sapiens
Entrez Gene ID	23274
Official Full Name	C-type lectin domain containing 16A
Also known as	Gop-1; KIAA0350
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000038532 MIM:611303; AllianceGenome:HGNC:29013
Map Location	16p13.13
Variation Type	SNP
refSNP ID	rs 12708716

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	Indian
Sample Size	197 Indian patients and 197 unrelated controls

Literature information of multiple sclerosis :

Pubmed ID	20952449
Year	2011
Title	Evaluation of the established non-MHC multiple sclerosis loci in an Indian population

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Although the power of this study was limited, our preliminary data suggest that disease susceptibility genes in MS in the Indian population may be similar to those of western populations
Result	In total, 197 Indian patients and 197 unrelated controls were analyzed. The most associated single nucleotide polymorphism (SNP) within this study was rs6897932 in the IL7R gene, which showed a strong protective effect in this data set (rs 6897932, OR 0.5543, 95% CI 0.37–0.78, p 0.0009727). Two other SNPs were nominally associated with MS in this dataset, namely CLEC16A rs 12708716 (p 0.0082, OR 1.478, 95% CI 1.106–1.975) and CD226 rs763361 (p 0.03971, OR 1.353, CI 1.014–1.805). For the majority of the remaining SNPs (7/14), the trend for association was in the same direction as in previous studies in the white population
Mechanism/Pathway	in Asian and Western MS. Analysis of the HLA class II genes, DRB1, DQA1 and DQB1 in a limited number of cases revealed the expected association with the European susceptibility haplotype DRB1*1501–DQB1*0602