Basic information of CIITA :
| Official Symbol of Gene | CIITA |
| Species | Homo sapiens |
| Entrez Gene ID | 4261 |
| Official Full Name | class II major histocompatibility complex transactivator |
| Also known as | C2TA; NLRA; MHC2TA; CIITAIV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179583 MIM:600005; AllianceGenome:HGNC:7067 |
| Map Location | 16p13.13 |
| Variation Type | SNP |
| refSNP ID | rs4774C |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 195 MS patients and 195 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 21962857 |
| Year | 2011 |
| Title | Herpesvirus active replication in multiple sclerosis A genetic control? |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | The results show that MS patients without HHV-6 active replication are better responders to interferon beta treatment than those with HHV-6 active replication |
| Result | a statistical significance was found for the two polymorphisms of MHC2TA when we compared MS patients with active replication and controls (p= 0.0000004 for rs4774C and p= 0.011 for rs3087456G) |
| Mechanism/Pathway | To study these questions we analyzed in a MS cohort: two polymorphisms of MHC2TA, a gene that has been previously associated with MS, and also with HHV-6, two polymorphisms of CD46, the gene that codes for the cellular receptor of HHV-6, and the HHV-6 replicative status through the analysis of HHV-6 genomes in serum samples by quantitative real-time PCR along two-year follow-up |
