Basic information of SOCS1 :
| Official Symbol of Gene | SOCS1 |
| Species | Homo sapiens |
| Entrez Gene ID | 8651 |
| Official Full Name | suppressor of cytokine signaling 1 |
| Also known as | JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; TIP-3; AISIMD; SOCS-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000185338 MIM:603597; AllianceGenome:HGNC:19383 |
| Map Location | 16p13.13 |
| Variation Type | SNP |
| refSNP ID | rs243324 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RR MS |
| Population | N/A |
| Sample Size | 30 MS patients and 30 age and gender matched healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 25701091 |
| Year | 2015 |
| Title | Expression of suppressor of cytokine signaling 1 (SOCS1) gene dramatically increases in relapsing–remitting multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | we found that SOCS1 gene overexpressed in RR-MS patients |
| Result | There were no significant differences in the genotype frequencies of SOCS1 rs243324 SNP between MS patients and the healthy controls. Moreover, the rs243324 SNP did not affect the expression level of SOCS1 mRNA in PBMCs of RR-MS patients |
| Mechanism/Pathway | SOCS1 regulates the signaling of cytokines via JAK–STAT pathway |
