Basic information of TREM2 :
| Official Symbol of Gene | TREM2 |
| Species | Homo sapiens |
| Entrez Gene ID | 54209 |
| Official Full Name | triggering receptor expressed on myeloid cells 2 |
| Also known as | PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000095970 MIM:605086; AllianceGenome:HGNC:17761 |
| Map Location | 6p21.1 |
| Variation Type | SNP |
| refSNP ID | rs75932628 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 1246 MS cases and 398 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31362167 |
| Year | 2019 |
| Title | TREM2 R47H (rs75932628) variant is unlikely to contribute to Multiple Sclerosis susceptibility and severity in a large Greek MS cohort |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | This variant does not seem to play a determining role in the pathogenesis of MS, although further studies examining the presence of TREM2 mutations in other, phylogenetically different populations and the epigenetic regulation of this gene are needed in order to thoroughly investigate its role in MS. |
| Result | Minor allele rs75932628-T frequency was reported between 0.0017 to 0.003 in European populations |
| Mechanism/Pathway | TREM2 is a signaling protein which participates in the innate immune system by implication to inflammation, proliferation and phagocytosis. |
