Basic information of MIR146A :
| Official Symbol of Gene | MIR146A |
| Species | Homo sapiens |
| Entrez Gene ID | 406938 |
| Official Full Name | microRNA 146a |
| Also known as | MIRN146; MIRN146A; miR-146a; miRNA146A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000283733 MIM:610566; miRBase:MI0000477; AllianceGenome:HGNC:31533 |
| Map Location | 5q33.3 |
| Variation Type | SNP |
| refSNP ID | rs2910164 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR–restriction fragment length polymorphism |
| Disease | MS |
| Disease subtype | N/A |
| Population | Iranian |
| Sample Size | 261 patients with MS and 250 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 33478974 |
| Year | 2020 |
| Title | Contribution of hsa-miR-146a and hsa-miR-223 gene variations in patients with multiple sclerosis reveals association of rs2910164 and rs1044165 with risk of multiple sclerosis susceptibility |
Results of multiple sclerosis :
| Risk Type | N/A |
| Main Result | this study determined that the C and T alleles of rs2910164 and rs1044165 are risk factors for MS in the Iranian population |
| Result | Allelic and genotypic associations between the SNPs and MS were evaluated by the data analysis conducted by SPSS V.20. The frequencies of rs2910164 and rs1044165 SNPs were significantly different between the patients with MS and healthy controls. C and T alleles in the variants rs2910164 and rs1044165, respectively, are associated with increased risk of MS. Such association was obtained in codominant, dominant, and overdominant models for both variants (OR ~3 and OR ~1.5, respectively). |
| Mechanism/Pathway | microRNAs (miRNAs), are involved in increased or decreased expression of molecules at the onset of MS or through its progression and exacerbation |
