Basic information of Spp1 :
| Official Symbol of Gene | Spp1 |
| Species | Homo sapiens |
| Entrez Gene ID | 6696 |
| Official Full Name | secreted phosphoprotein 1 |
| Also known as | OPN; BNSP; BSPI; ETA-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000118785 MIM:166490; AllianceGenome:HGNC:11255 |
| Map Location | 4q22.1 |
| Variation Type | SNP |
| refSNP ID | rs 4754 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Caucasians |
| Sample Size | 1056 affected individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 12928913 |
| Year | 2003 |
| Title | Osteopontin gene and clinical severity of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | The four SNPs finally considered in our analysis include two located in coding regions of the osteopontin gene and two from non-coding regions of exon 7. Although none of these variations lead to amino-acid changes they may still be functionally important by altering mRNA stability or localization or be in linkage disequilibrium with functionally important variants located in other parts of the osteopontin gene |
| Mechanism/Pathway | After typing the first 286 affected and 192 control individuals, heterozygosity rates for the SNPs were examined. No heterozygous individuals were identified for SNPs 3 and 5 and heterozygosity rates for SNPs 7 and 8 were less than 5 % in cases and controls.These four SNPs were therefore dropped from the study and only SNPs 1, 2, 4 and 6 were used to complete the analysis |
