Basic information of TNFRSF1A :
| Official Symbol of Gene | TNFRSF1A |
| Species | Homo sapiens |
| Entrez Gene ID | 7132 |
| Official Full Name | TNF receptor superfamily member 1A |
| Also known as | FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000067182 MIM:191190; AllianceGenome:HGNC:11916 |
| Map Location | 12p13.31 |
| Variation Type | mutation |
| refSNP ID | R92Q |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Argentina |
| Sample Size | 90 MS patients and 78 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 21567205 |
| Year | 2012 |
| Title | TNFRSF1A [corrected] R92Q mutation, autoinflammatory symptoms and multiple sclerosis in a cohort from Argentina |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | We found a marginally non-significant increase in the frequency of mutants carriers in the cohort of patients (5.5%) as compared to the control group (1.3%), P = 0.1; OR = 4.5; 95% CI 0.53–40.3. |
| Mechanism/Pathway | It is caused by mutations in the tumor necrosis factor (TNF) receptor superfamily 1A (TNFRSF1A; MIM 191190) gene, which encodes the TNFa 55-kd receptor. |
