Basic information of AGER :
| Official Symbol of Gene | AGER |
| Species | Homo sapiens |
| Entrez Gene ID | 177 |
| Official Full Name | advanced glycosylation end-product specific receptor |
| Also known as | RAGE; sRAGE; SCARJ1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204305 MIM:600214; AllianceGenome:HGNC:320 |
| Map Location | 6p21.32 |
| Variation Type | homozygote |
| refSNP ID | AA |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS, SPMS |
| Population | N/A |
| Sample Size | 168 patients with MS were enrolled; 136 healthy blood donors served as controls |
Literature information of multiple sclerosis :
| Pubmed ID | 19757202 |
| Year | 2009 |
| Title | RAGE gene polymorphisms in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result |
The AA homozygote variants were detected in 8% of the patients with MS, as compared with 19% of healthy controls (OR=2.75; 95% CI=1.319 |
| Mechanism/Pathway | The receptor for advanced glycation end products (RAGE) is a member of immunoglobulin superfamily of cell surface molecules. |
