Basic information of GC :
| Official Symbol of Gene | GC |
| Species | Homo sapiens |
| Entrez Gene ID | 2638 |
| Official Full Name | GC vitamin D binding protein |
| Also known as | DBP; VDB; GRD3; VDBG; VDBP; GcMAF; DBP/GC; Gc-MAF; DBP-maf; HEL-S-51 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000145321 MIM:139200; AllianceGenome:HGNC:4187 |
| Map Location | 4q13.3 |
| Variation Type | SNP |
| refSNP ID | rs4588 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | PPMS, SPMS, RRMS |
| Population | Sicilian |
| Sample Size | 100 MS patients and 92 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 27904983 |
| Year | 2017 |
| Title | VDBP, CYP27B1, and 25-Hydroxyvitamin D Gene Polymorphism Analyses in a Group of Sicilian Multiple Sclerosis Patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | We did not observe any statically significant difference in the distribution of genotypic VDBP variants between the study groups. |
| Mechanism/Pathway | VDBP has a role in immune system as a chemotactic factor for neutrophil leucocytes and osteoclast activation. |
