Basic information of BDNF :
| Official Symbol of Gene | BDNF |
| Species | Homo sapiens |
| Entrez Gene ID | 627 |
| Official Full Name | brain derived neurotrophic factor |
| Also known as | ANON2; BULN2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000176697 MIM:113505; AllianceGenome:HGNC:1033 |
| Map Location | 11p14.1 |
| Variation Type | polymorphisms |
| refSNP ID | 196 G/G |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS, SPMS |
| Population | polish |
| Sample Size | 230 patients (63 men and 167 women) with MS and 177 unrelated, sex matched (63 males and 114 females) healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 18061279 |
| Year | 2008 |
| Title | BDNF A196G and C270T gene polymorphisms and susceptibility to multiple sclerosis in the Polish population. Gender differences |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | In females, the same 270C/T genotype conferred a highly significant risk of MS, whereas the 196G/G genotype was associated with a less pronounced but still significantly increased risk of MS. |
| Mechanism/Pathway | contribute to neuronal survival, axonal and neuronal repair |
