Basic information of IL4 :
| Official Symbol of Gene | IL4 |
| Species | Homo sapiens |
| Entrez Gene ID | 3565 |
| Official Full Name | interleukin 4 |
| Also known as | BSF1; IL-4; BCGF1; BSF-1; BCGF-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000113520 MIM:147780; AllianceGenome:HGNC:6014 |
| Map Location | 5q31.1 |
| Variation Type | genotype |
| refSNP ID | E1(33) CC |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | PPMS |
| Population | N/A |
| Sample Size | 122 sporadic cases with MS and 244 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 12667657 |
| Year | 2003 |
| Title | A population-based study of IL4 polymorphisms in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotype risk |
| Main Result | Positive |
| Result | We screened the promoter region, exons 1 – 4 and their splice sites for polymorphisms and tested the association between novel polymorphisms E1(33)*C ! T and I3(2580)*C ! A, and the established 5V( 523)*C ! T and I3(709)*VNTR polymorphisms with susceptibility to, age of onset in, and course and severity of MS in sporadic cases. |
| Mechanism/Pathway | IL-4 inhibits the synthesis of IFNg |
