Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | polymorphisms |
| refSNP ID | HLA-DRB1*15:01 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 268 SLE patients and 90 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 23379431 |
| Year | 2013 |
| Title | Serum concentration of immunoglobulin G-type antibodies against the whole Epstein-Barr nuclear antigen 1 and its aa35-58 or aa398-404 fragments in the sera of patients with systemic lupus erythematosus and multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Carriers of the HLADRB1*15:01 allele were significantly more common among the MS patients than in the group of healthy controls.When the subjects were divided according to sex, the frequency of the HLA-DRB1*15:01 carrier state was significantly higher among MS patients than among healthy subjects, both in females and in males (P = 0·0084 and P = 0·0058). |
| Mechanism/Pathway | N/A |
