Basic information of HLA-DQB1 :
| Official Symbol of Gene | HLA-DQB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3119 |
| Official Full Name | major histocompatibility complex, class II, DQ beta 1 |
| Also known as | IDDM1; CELIAC1; HLA-DQB |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179344 MIM:604305; AllianceGenome:HGNC:4944 |
| Map Location | 6p21.32 |
| Variation Type | polymorphisms |
| refSNP ID | *0502 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | Peripheral blood |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | MSr, MSc, MSb, MSU |
| Population | Sardinian |
| Sample Size | 116 MSU patients, 67 of whom had a relapsing-remitting form (MSr), 28 of whom had a chronic progressive from-the-onset form(MSc), and 21 of whom had a benign form (MSb), 32 patients with MSR, 19 parents and 27 healthy siblings of patients with MSR, and 86 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 8442703 |
| Year | 1993 |
| Title | Role of predisposing and protective HLA-DQA and HLA-DQB alleles in Sardinian multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Among the DQB genes, the DQB1 *0502 allele was diminished in patients with MSr vs controls (Pc=.04),while the sum of DQB1*0201 and *0302 alleles was significantly in reased in patients with MSR vs controls (Pc=.003). |
| Mechanism/Pathway | N/A |
