Basic information of APOE :
| Official Symbol of Gene | APOE |
| Species | Homo sapiens |
| Entrez Gene ID | 348 |
| Official Full Name | apolipoprotein E |
| Also known as | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 |
| Map Location | 19q13.32 |
| Variation Type | genotype |
| refSNP ID | E o4 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | RRMS, SPMS, PPMS |
| Population | Spanish |
| Sample Size | 153 MS Caucasian patients |
Literature information of multiple sclerosis :
| Pubmed ID | 16459715 |
| Year | 2006 |
| Title | No association of apolipoprotein E epsilon4 genotype with faster progression or less recovery of relapses in a Spanish cohort of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | APOE o4 polymorphism is not associated with a more severe clinical course and does not appear to influence recovery of exacerbations. |
| Mechanism/Pathway | APOE is a glycoprotein involved in lipid transport and cholesterol homeostasis; moreover, it is the major lipid carrier in the brain. |
