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Basic information of CD6 :

Official Symbol of Gene CD6
Species Homo sapiens
Entrez Gene ID 923
Official Full Name CD6 molecule
Also known as TP120
Gene Type protein coding
dbXrefs Ensembl:ENSG00000013725 MIM:186720; AllianceGenome:HGNC:1691
Map Location 11q12.2
Variation Type SNP
refSNP ID rs2237997

Sample information of multiple sclerosis:

Detected Sample blood
Sample Detail N/A
Detected Method N/A
Disease MS
Disease subtype N/A
Population N/A
Sample Size 2265 MS patients and 2600 healthy controls

Literature information of multiple sclerosis :

Pubmed ID 23638056
Year 2013
Title Fine mapping and functional analysis of the multiple sclerosis risk gene CD6

Results of multiple sclerosis :

Risk Type Disease risk
Main Result Negative
Result We identified association of haplotypes composed of two non synonymous SNPs [rs11230563 (R225W) and rs2074225(A257V)] in the 2nd SRCR domain with susceptibility to MS.
Mechanism/Pathway CD6 is a cell surface scavenger receptor involved in T-cell activation and proliferation, as well as in thymocyte differentiation.