Basic information of STAT3 :
| Official Symbol of Gene | STAT3 |
| Species | Homo sapiens |
| Entrez Gene ID | 6774 |
| Official Full Name | signal transducer and activator of transcription 3 |
| Also known as | signal transducer and activator of transcription 3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168610 MIM:102582; AllianceGenome:HGNC:11364 |
| Map Location | 17q21.2 |
| Variation Type | methylation |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood mononuclear cells |
| Detected Method | qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 50 MS patients and 50 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 33375941 |
| Year | 2020 |
| Title | Epigenetic mechanisms shape the underlining expression regulatory mechanisms of the STAT3 in multiple sclerosis disease |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Our study demonstrated that the level of STAT3 methylation decreased in relapsing–remitting MS patient compared to control groups, which the decreases were statistically signifcant. |
| Mechanism/Pathway | signal transducer and activator of transcription 3 (STAT3) play a critical role in the induction of Th17 cell diferentiation and inhibition of Treg cell development. |
