Basic information of GNB3 :
| Official Symbol of Gene | GNB3 |
| Species | Homo sapiens |
| Entrez Gene ID | 2784 |
| Official Full Name | G protein subunit beta 3 |
| Also known as | HG2D; CSNB1H |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000111664 MIM:139130; AllianceGenome:HGNC:4400 |
| Map Location | 12p13.31 |
| Variation Type | polymorphisms |
| refSNP ID | C825T |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | venous blood |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS, SCPMS, PCPMS |
| Population | N/A |
| Sample Size | MS (n = 253) |
Literature information of multiple sclerosis :
| Pubmed ID | 12270649 |
| Year | 2002 |
| Title | Frequencies of the G-protein beta3 subunit C825T polymorphism and the delta 32 mutation of the chemokine receptor-5 in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Apart from a trend to a reduced frequency of d32 CCR5 and increased GNB3 825T polymorphism in primary chronic progressive patients, numbers did not reach statistical significance in any group of MS. |
| Mechanism/Pathway | influence autoreactive T-cell-actions like proliferation and chemotaxis across the blood–brain barrier via chemokine receptors (CCR) and G-protein coupled activating mechanisms. |
