Basic information of CCR5 :
| Official Symbol of Gene | CCR5 |
| Species | Homo sapiens |
| Entrez Gene ID | 1234 |
| Official Full Name | C-C motif chemokine receptor 5 |
| Also known as | CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000160791 MIM:601373; AllianceGenome:HGNC:1606 |
| Map Location | 3p21.31 |
| Variation Type | mutation |
| refSNP ID | d32 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | venous blood |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS, SCPMS, PCPMS |
| Population | N/A |
| Sample Size | MS (n = 253) |
Literature information of multiple sclerosis :
| Pubmed ID | 12270649 |
| Year | 2002 |
| Title | Frequencies of the G-protein beta3 subunit C825T polymorphism and the delta 32 mutation of the chemokine receptor-5 in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Apart from a trend to a reduced frequency of d32 CCR5 and increased GNB3 825T polymorphism in primary chronic progressive patients, numbers did not reach statistical significance in any group of MS. |
| Mechanism/Pathway | influence autoreactive T-cell-actions like proliferation and chemotaxis across the blood–brain barrier via chemokine receptors (CCR) and G-protein coupled activating mechanisms. |
