Basic information of TNFRSF10B :
| Official Symbol of Gene | TNFRSF10B |
| Species | Homo sapiens |
| Entrez Gene ID | 8795 |
| Official Full Name | TNF receptor superfamily member 10b |
| Also known as | DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000120889 MIM:603612; AllianceGenome:HGNC:11905 |
| Map Location | 8p21.3 |
| Variation Type | SNP |
| refSNP ID | rs1001793 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood nucleated cells |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | RRMS, SPMS, PPMS |
| Population | Spanish |
| Sample Size | 628 MS patients and 660 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 21814551 |
| Year | 2011 |
| Title | TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | three SNPs showing uncorrected p values,0.05 were successfully replicated: rs4894559 in TRAIL gene; rs4872077, in TRAILR-1 gene; and rs1001793 in TRAILR-2 gene. |
| Mechanism/Pathway | The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. |
