Basic information of TPH2 :
| Official Symbol of Gene | TPH2 |
| Species | Homo sapiens |
| Entrez Gene ID | 121278 |
| Official Full Name | tryptophan hydroxylase 2 |
| Also known as | NTPH; ADHD7 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000139287 MIM:607478; AllianceGenome:HGNC:20692 |
| Map Location | 12q21.1 |
| Variation Type | SNP |
| refSNP ID | rs4570625– rs10506645 TC |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | RRMS, SPMS, PPMS |
| Population | Finnish |
| Sample Size | 590 subjects (193 MS patients and 397 healthy controls) |
Literature information of multiple sclerosis :
| Pubmed ID | 22698518 |
| Year | 2012 |
| Title | Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The haplotype rs4570625-rs10506645TT of TPH2 gene was associated with the risk of severe disability in primary progressive MS(PPMS), while haplotype rs4570625-rs10506645TC appeared to be protective against disability in secondary progressive MS (SPMS). |
| Mechanism/Pathway | in melatonin biosynthesis pathway |
