Basic information of MTNR1B :
| Official Symbol of Gene | MTNR1B |
| Species | Homo sapiens |
| Entrez Gene ID | 4544 |
| Official Full Name | melatonin receptor 1B |
| Also known as | MT2; FGQTL2; MEL-1B-R |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134640 MIM:600804; AllianceGenome:HGNC:7464 |
| Map Location | 11q14.3 |
| Variation Type | SNP |
| refSNP ID | rs10830963– rs4753426 GC |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | RRMS, SPMS, PPMS |
| Population | Finnish |
| Sample Size | 590 subjects (193 MS patients and 397 healthy controls) |
Literature information of multiple sclerosis :
| Pubmed ID | 22698518 |
| Year | 2012 |
| Title | Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | In the MTNR1B gene, the haplotype rs10830963-rs4753426GC was associated with the risk of SPMS, whereas another haplotype rs10830963-rs4753426GT showed an association with the risk of PPMS. |
| Mechanism/Pathway | membrane receptor gene (Melatonin receptor 1B, MTNR1B) essential for the function of melatonin |
