Basic information of Galc :
| Official Symbol of Gene | Galc |
| Species | Homo sapiens |
| Entrez Gene ID | 14420 |
| Official Full Name | galactosylceramidase |
| Also known as | twi; Gacy; twitcher; 2310068B06Rik; A930008M05Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000021003 AllianceGenome:MGI:95636 |
| Map Location | 12 E; 12 49.83 cM |
| Variation Type | mutation |
| refSNP ID | GALC +/- |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | N/A |
| Detected Method | qPCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57Bl/6J |
| Sample Size | n = 3 |
Literature information of multiple sclerosis :
| Pubmed ID | 28575206 |
| Year | 2017 |
| Title | Heterozygote galactocerebrosidase (GALC) mutants have reduced remyelination and impaired myelin debris clearance following demyelinating injury |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | thus provide a potential functional link between GALC variants and increased MS susceptibility, particularly due to the failure of remyelination associated with progressive MS. |
| Mechanism/Pathway | N/A |
