Details

Home Details


Basic information of IFNG :

Official Symbol of Gene IFNG
Species Homo sapiens
Entrez Gene ID 3458
Official Full Name interferon gamma
Also known as IFG; IFI; IMD69
Gene Type protein coding
dbXrefs Ensembl:ENSG00000111537 MIM:147570; AllianceGenome:HGNC:5438
Map Location 12q15
Variation Type marker
refSNP ID D12S375

Sample information of multiple sclerosis:

Detected Sample blood
Sample Detail venous blood
Detected Method PCR
Disease MS
Disease subtype N/A
Population Sardinians
Sample Size 217 simplex families(ie one affected sib, two healthy parents

Literature information of multiple sclerosis :

Pubmed ID 12486605
Year 2002
Title Linkage disequilibrium analysis of chromosome 12q14-15 in multiple sclerosis: delineation of a 118-kb interval around interferon-gamma (IFNG) that is involved in male versus female differential susceptibility

Results of multiple sclerosis :

Risk Type Disease risk
Main Result Positive
Result Only D12S375 was weakly associated with MS in the ‘low HLA-risk’ group (ie individuals carrying neither DRB1*03 nor DRB1*04 alleles) (P 0.024), especially in men (P 0.049).
Mechanism/Pathway N/A