Basic information of IL4 :
| Official Symbol of Gene | IL4 |
| Species | Homo sapiens |
| Entrez Gene ID | 3565 |
| Official Full Name | interleukin 4 |
| Also known as | BSF1; IL-4; BCGF1; BSF-1; BCGF-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000113520 MIM:147780; AllianceGenome:HGNC:6014 |
| Map Location | 5q31.1 |
| Variation Type | SNP |
| refSNP ID | rs2243250 |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Rhein-Ruhr area (Germany) |
| Sample Size | 869 multiple sclerosis (MS) patients and 595 healthy blood donors |
Literature information of multiple sclerosis :
| Pubmed ID | 17855802 |
| Year | 2007 |
| Title | Sex specifically associated promoter polymorphism in multiple sclerosis affects interleukin 4 expression levels |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | In dual luciferase assays of cultured Jurkat cells the cloned promoter comprising the 589 T allele leads to higher expression as compared to the respective construct with the C allele. |
| Mechanism/Pathway | Dependent on the immunological situation, the 589 C/T variation may contribute to susceptibility for several autoimmune diseases by varying IL4 expression levels and hence modulation of the anti-inflammatory downregulation. |
