Basic information of SERPINE1 :
| Official Symbol of Gene | SERPINE1 |
| Species | Homo sapiens |
| Entrez Gene ID | 5054 |
| Official Full Name | serpin family E member 1 |
| Also known as | PAI; PAI1; PAI-1; PLANH1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000106366 MIM:173360; AllianceGenome:HGNC:8583 |
| Map Location | 7q22.1 |
| Variation Type | polymorphism |
| refSNP ID | 5G5G |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Finnish patients |
| Sample Size | 104 Finnish patients including 59 women and 45 men |
Literature information of multiple sclerosis :
| Pubmed ID | 10802801 |
| Year | 2000 |
| Title | Plasminogen activator inhibitor 1 gene and risk of MS in women |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Women with RRMS had the most significant increase in 5G5G genotype frequency (OR, 2.48; p 5 0.028). |
| Mechanism/Pathway | Moreover, 4G and 5G alleles bind a transcriptional activator, but the 5G allele also binds a repressor protein to an overlapping site, which leads to a decreased basal level of PAI-1 transcription. |
