Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | polymorphism |
| refSNP ID | HLADRB1*04:01, *04:08, *16:01 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | sequencing-based typing using generic sequencing of exon 2 |
| Disease | MS |
| Disease subtype | N/A |
| Population | Northern European heritage |
| Sample Size | a discovery cohort (n=268) and a validation cohort (n=825) |
Literature information of multiple sclerosis :
| Pubmed ID | 21482927 |
| Year | 2011 |
| Title | Influence of the HLA-DRB1 genotype on antibody development to interferon beta in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | In the discovery and validation cohorts, HLADRB1*04:01, *04:08, *16:01 were identified as genetic markers that are associated with an increased risk of anti-interferon beta antibody development (P.05). |
| Mechanism/Pathway | N/A |
