Basic information of CTLA4 :

Official Symbol of Gene	CTLA4
Species	Homo sapiens
Entrez Gene ID	1493
Official Full Name	cytotoxic T-lymphocyte associated protein 4
Also known as	CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000163599 MIM:123890; AllianceGenome:HGNC:2505
Map Location	2q33.2
Variation Type	polymorphism
refSNP ID	-1722 T C

Sample information of multiple sclerosis:

Detected Sample	blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	RRMS,PPMS
Population	Iranian
Sample Size	153 Iranian patients and 190 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	19737153
Year	2009
Title	CTLA4 exon 1 and promoter polymorphisms in patients with multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	The distribution of -1722 T C, -1661 A G, -318 C T and +49 A G (TACA) haplotype, from the contrary, was observed to be significantly increased among controls.
Mechanism/Pathway	Following surface expression, CTLA4 is reported to suppress T cell function by inducing indoleamine 2,3-dioxygenase metabolism in dendritic cells.