Basic information of CTLA4 :
| Official Symbol of Gene | CTLA4 |
| Species | Homo sapiens |
| Entrez Gene ID | 1493 |
| Official Full Name | cytotoxic T-lymphocyte associated protein 4 |
| Also known as | CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000163599 MIM:123890; AllianceGenome:HGNC:2505 |
| Map Location | 2q33.2 |
| Variation Type | SNP |
| refSNP ID | TGCG |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS |
| Population | Iranian |
| Sample Size | 153 Iranian patients and 190 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 19737153 |
| Year | 2009 |
| Title | CTLA4 exon 1 and promoter polymorphisms in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | List of observed haplotypes among patients and healthy controls and the statistical analyses are summarized in Table 3. |
| Mechanism/Pathway | Following surface expression, CTLA4 is reported to suppress T cell function by inducing indoleamine 2,9-dioxygenase metabolism in dendritic cells. |
