Basic information of HLA-DQB1 :

Official Symbol of Gene	HLA-DQB1
Species	Homo sapiens
Entrez Gene ID	3119
Official Full Name	major histocompatibility complex, class II, DQ beta 1
Also known as	IDDM1; CELIAC1; HLA-DQB
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000179344 MIM:604305; AllianceGenome:HGNC:4944
Map Location	6p21.32
Variation Type	polymorphism
refSNP ID	DQB1*0302

Sample information of multiple sclerosis:

Detected Sample	brain
Sample Detail	N/A
Detected Method	N/A
Disease	EAE
Disease subtype	N/A
Population	HLA transgenic mice
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	16194572
Year	2005
Title	HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice

Results of multiple sclerosis :

Risk Type	Phenotypic risk
Main Result	Positive
Result	This would suggest that the presence of more than one susceptible allele, namely HLA DRB1*1502 and DQB1*0302 resulted in enhanced severity of disease in the DRB1*1502/DQB1*0302 mice, possibly due to the additional selection and expansion of potential autoreactive T cells.
Mechanism/Pathway	The other possible mechanism for the enhanced severity of disease in HLA DRB1*1502/DQB1*0302 mice may involve antigen presentation by specific HLA molecules as well as TCR repertoire selection.