Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | polymorphism |
| refSNP ID | DRB1*1502 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | EAE |
| Disease subtype | N/A |
| Population | HLA transgenic mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 16194572 |
| Year | 2005 |
| Title | HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | This would suggest that the presence of more than one susceptible allele, namely HLA DRB1*1502 and DQB1*0302 resulted in enhanced severity of disease in the DRB1*1502/DQB1*0302 mice, possibly due to the additional selection and expansion of potential autoreactive T cells. |
| Mechanism/Pathway | The other possible mechanism for the enhanced severity of disease in HLA DRB1*1502/DQB1*0302 mice may involve antigen presentation by specific HLA molecules as well as TCR repertoire selection. |
