Basic information of PLA2G7 :
| Official Symbol of Gene | PLA2G7 |
| Species | Homo sapiens |
| Entrez Gene ID | 7941 |
| Official Full Name | phospholipase A2 group VII |
| Also known as | PAFAD; PAFAH; LP-PLA2; LDL-PLA2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000146070 MIM:601690; AllianceGenome:HGNC:9040 |
| Map Location | 6p12.3 |
| Variation Type | polymorphism |
| refSNP ID | TT |
Sample information of multiple sclerosis:
| Detected Sample | leukocytes |
| Sample Detail | blood gene |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | OS-MS,C-MS |
| Population | Japanese |
| Sample Size | 216 patients and 213 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 15081260 |
| Year | 2004 |
| Title | Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Negative |
| Result | These findings suggest that the PAF-AH gene missense mutation has no relation to either susceptibility or severity of C-MS, yet its activity is down-regulated, and that the mutation has no relation with susceptibility of OS-MS, yet it may confer the severity of female OS-MS. |
| Mechanism/Pathway | Such a decrease of PAF-AH activity may in part be responsible for the reported increase of PAF in MS plasma and CSF, and therefore could contribute to the inflammation and vascular permeability changes in the CNS of MS. |
