Basic information of MIR146A :
| Official Symbol of Gene | MIR146A |
| Species | Homo sapiens |
| Entrez Gene ID | 406938 |
| Official Full Name | microRNA 146a |
| Also known as | MIRN146; MIRN146A; miR-146a; miRNA146A |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000283733 MIM:610566; miRBase:MI0000477; AllianceGenome:HGNC:31533 |
| Map Location | 5q33.3 |
| Variation Type | polymorphism |
| refSNP ID | rs2910164 G>C |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | real-time PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 525 patients (276 female, 103 male),568 unrelated healthy blood donors (376 female, 192 male) |
Literature information of multiple sclerosis :
| Pubmed ID | 25591770 |
| Year | 2015 |
| Title | Genetic association of MiR-146a with multiple sclerosis susceptibility in the Chinese population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Further stratification analysis by subgroup revealed that the miR146a rs2910164 C allele conferred a higher risk of developing relapsing–remitting MS (RRMS (P=0.018). |
| Mechanism/Pathway | It is likely that the rs2910164 G>C variation is linked with stronger inflammatory responses. |
