Basic information of LIF :
| Official Symbol of Gene | LIF |
| Species | Homo sapiens |
| Entrez Gene ID | 3976 |
| Official Full Name | LIF interleukin 6 family cytokine |
| Also known as | CDF; DIA; HILDA; MLPLI |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000128342 MIM:159540; AllianceGenome:HGNC:6596 |
| Map Location | 22q12.2 |
| Variation Type | SNP |
| refSNP ID | SNP3951 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | MS patients,rheumatoid arthritis(RA) patients,healthy controls |
| Sample Size | MS patients (n = 110), rheumatoid arthritis (RA) patients (n = 120) and healthy controls (HC, n = 109) |
Literature information of multiple sclerosis :
| Pubmed ID | 16263181 |
| Year | 2006 |
| Title | No association of leukemia inhibitory factor (LIF) DNA polymorphisms with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | disease risk |
| Main Result | Negative |
| Result | In summary, no association was found between the studied LIF DNA polymorphisms and the prevalence of MS indicating that these polymorphisms are not involved in determining disease susceptibility. |
| Mechanism/Pathway | Indeed, these polymorphisms might have an impact on the neuroprotective effects of LIF, thus compromising tissue repair and disease recovery. |
