Basic information of TYK2 :
| Official Symbol of Gene | TYK2 |
| Species | Homo sapiens |
| Entrez Gene ID | 7297 |
| Official Full Name | tyrosine kinase 2 |
| Also known as | JTK1; IMD35 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000105397 MIM:176941; AllianceGenome:HGNC:12440 |
| Map Location | 19p13.2 |
| Variation Type | SNP |
| refSNP ID | rs34536443 |
Sample information of multiple sclerosis:
| Detected Sample | Venous blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | PPMS.RRMS,SPMS |
| Population | Caucasian |
| Sample Size | 1003 patients with MS |
Literature information of multiple sclerosis :
| Pubmed ID | 22732448 |
| Year | 2012 |
| Title | Genotype-phenotype correlation for non-HLA disease associated risk alleles in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | No SNP was associated with systematic deflection in time to disability milestones, age at onset or time to secondary progression. |
| Mechanism/Pathway | Tyk2 is a dendritic cell signalling protein which causes a shift towards the Th1 response in response to IL-12, which may be important in early inflammatory stages of MS. |
