Basic information of Tnf :
| Official Symbol of Gene | Tnf |
| Species | Mus musculus |
| Entrez Gene ID | 21926 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798 |
| Map Location | 17 B1; 17 18.59 cM |
| Drug | AST treatment |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57BL/6 mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 25150364 |
| Year | 2014 |
| Title | Astragalosides from Radix Astragali benefits experimental autoimmune encephalomyelitis in C57BL /6 mice at multiple levels |
Results of multiple sclerosis :
| Result | However, it decreased IFNγ (p < 0.01), TNFα (p < 0.01) and IL6 (p < 0.05) levels. |
| Mechanism/pathway | Deficiency of p53 increases the severity of EAE possibly by elongating the survival of inflammatory cells in the CNS, therefore, enhancing the production of pro inflammatory cytokines such as IL-6, TNF-α and IFN-γ. |
