Basic information of Il12b :

Official Symbol of Gene	Il12b
Species	Mus musculus
Entrez Gene ID	16160
Official Full Name	interleukin 12b
Also known as	p40; Il-12b; Il12p40; Il-12p40
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000004296 AllianceGenome:MGI:96540
Map Location	11 B1.1; 11 25.94 cM
Drug	Human adipose-derived mesenchymal stem cells
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	23369732
Year	2013
Title	Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity

Results of multiple sclerosis :

Result	In the presence of Adi-IL-10-MSCs, Adi-eGFP-MSCs or their CM however, IL-6, IL-12p40, and TNF-a secretion was significant reduced.
Mechanism/pathway	This protective effect was associated with several anti inflammatory response mechanisms, including a reduction in peripheral T-cell proliferative responses, a decrease in pro inflammatory cytokine secretion as well as a preferential inhibition of Th17-mediated neuroinflammation.