Basic information of Tnf :

Official Symbol of Gene	Tnf
Species	Mus musculus
Entrez Gene ID	21926
Official Full Name	tumor necrosis factor
Also known as	DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798
Map Location	17 B1; 17 18.59 cM
Drug	Human adipose-derived mesenchymal stem cells
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	23369732
Year	2013
Title	Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity

Results of multiple sclerosis :

Result	In the presence of Adi-IL-10-MSCs, Adi-eGFP-MSCs or their CM however, IL-6, IL-12p40, and TNF-a secretion was significant reduced.
Mechanism/pathway	This protective effect was associated with several anti inflammatory response mechanisms, including a reduction in peripheral T-cell proliferative responses, a decrease in pro inflammatory cytokine secretion as well as a preferential inhibition of Th17-mediated neuroinflammation.