Details

Home Details


Basic information of Pdp2 :

Official Symbol of Gene Pdp2
Species Mus musculus
Entrez Gene ID 382051
Official Full Name pyruvate dehydrogenase phosphatase catalytic subunit 2
Also known as Gm1705; mKIAA1348; 4833426J09Rik
Gene Type protein coding
dbXrefs Ensembl:ENSMUSG00000048371 AllianceGenome:MGI:1918878
Map Location 8; 8 D3
Drug ICER/CREM gene
Interaction Type inhibitor

Sample information of multiple sclerosis:

Descent C57BL/6J mice
Disease EAE

Literature information of multiple sclerosis :

Pubmed ID 30150402
Year 2018
Title Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation

Results of multiple sclerosis :

Result suppresses the expression of PDP2.
Mechanism/pathway PDP2 suppresses Th17 differentiation and Th17 cell-specific PDP2 inhibition accelerates EAE.