Basic information of Il10 :

Official Symbol of Gene	Il10
Species	Mus musculus
Entrez Gene ID	16153
Official Full Name	interleukin 10
Also known as	CSIF; If2a; Il-10
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000016529 AllianceGenome:MGI:96537
Map Location	1 E4; 1 56.89 cM
Drug	gene therapy with autoAg
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57Bl/6J mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	19277013
Year	2009
Title	Tolerance induction in experimental autoimmune encephalomyelitis using non-myeloablative hematopoietic gene therapy with autoantigen

Results of multiple sclerosis :

Result	In conclusion, this study demonstrates that a cell therapy using BMC expressing an autoAg can induce Ag-specific tolerance and ameliorate established EAE even in a nonmyeloablative setting.
Mechanism/pathway	Both IL-5 and IL-10 were reported to mediate Tr1 effects.