Basic information of Il7r :

Official Symbol of Gene	Il7r
Species	Mus musculus
Entrez Gene ID	16197
Official Full Name	interleukin 7 receptor
Also known as	CD127; IL-7Ralpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000003882 AllianceGenome:MGI:96562
Map Location	15 A1; 15 4.16 cM
Drug	novel antisense oligonucleotides (ASOs)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	35613883
Year	2022
Title	Antisense modulation of IL7R splicing to control sIL7R expression in human CD4+ T cells

Results of multiple sclerosis :

Result	Supporting their potential for therapeutic targeting, we showed that lead anti sIL7R ASOs correct the enhanced exon 6 exclusion imposed by the MS risk allele of rs6897932, whereas lead pro-sIL7R ASOs phenocopy it.
Mechanism/pathway	In this study, we identified novel antisense oligonucleotides (ASOs) that effectively control the inclusion (anti-sIL7R ASOs) or exclusion (pro-sIL7R ASOs) of this exon in a dose-dependent fashion.