Basic information of Il12b :

Official Symbol of Gene	Il12b
Species	Rattus norvegicus
Entrez Gene ID	64546
Official Full Name	interleukin 12B
Also known as	Il12
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000004380 AllianceGenome:RGD:628704
Map Location	10q21
Drug	siRNA-IL-23 treatment
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	rats
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	22989513
Year	2013
Title	Therapeutic gene silencing with siRNA for IL-23 but not for IL-17 suppresses the development of experimental autoimmune encephalomyelitis in rats

Results of multiple sclerosis :

Result	siRNA-IL-23 treatment downregulated IL-12, IL-17 and IL-23 mRNAs.
Mechanism/pathway	First, as shown in the present study, siRNA-IL-23 treatment suppressed the development of both Th1 and Th17 cells and related key cytokines.