Basic information of Tnf :

Official Symbol of Gene	Tnf
Species	Mus musculus
Entrez Gene ID	21926
Official Full Name	tumor necrosis factor
Also known as	DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798
Map Location	17 B1; 17 18.59 cM
Drug	HSV-1-mediated IL-1 receptor antagonist gene therapy
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl/6J mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	16929354
Year	2007
Title	HSV-1-mediated IL-1 receptor antagonist gene therapy ameliorates MOG(35-55)-induced experimental autoimmune encephalomyelitis in C57BL/6 mice

Results of multiple sclerosis :

Result	Proinflammatory cytokine mRNAs are downregulated in the brain from C57BL/6 EAE mice.
Mechanism/pathway	The decreased number of CNS-infiltrating macrophages can determine decreased levels of monocyte-related proinflammatory cytokine mRNA such as IL-1b, IL-6 and TNF-a.