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Basic information of Il23a :

Official Symbol of Gene Il23a
Species Mus musculus
Entrez Gene ID 83430
Official Full Name interleukin 23, alpha subunit p19
Also known as p19; IL-23
Gene Type protein coding
dbXrefs Ensembl:ENSMUSG00000025383 AllianceGenome:MGI:1932410
Map Location 10; 10 D3
Drug herpes simplex virus-based gene therapy
Interaction Type inhibitor

Sample information of multiple sclerosis:

Descent BALB/c mice
Disease EAE

Literature information of multiple sclerosis :

Pubmed ID 15196670
Year 2004
Title IL-4 is the key regulator in herpes simplex virus-based gene therapy of BALB/c experimental autoimmune encephalomyelitis

Results of multiple sclerosis :

Result On the contrary, in the R8308 (IL-10 expression) treated mice, the expression of IL-23 was decreased.
Mechanism/pathway however, a downregulating role for IL-10 in control of IL-23 expression.